Abstract
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Aspergillus / chemistry*
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Astrocytoma / metabolism
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Nervous System Neoplasms / metabolism
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Receptors, Neurokinin-1 / drug effects
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Spectrophotometry, Ultraviolet
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Stereoisomerism
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Substance P / antagonists & inhibitors*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Receptors, Neurokinin-1
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Spiro Compounds
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spiroquinazoline
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Substance P